Description
NAD+ (Nicotinamide Adenine Dinucleotide) is an essential cellular coenzyme that plays a central role in energy metabolism, DNA maintenance, and a wide range of cell signaling functions. It is best known for acting as a key electron carrier in metabolic reactions, supporting the biochemical processes that convert nutrients into usable cellular energy.
NAD+ is involved throughout major energy-producing pathways including glycolysis, the citric acid (TCA) cycle, and oxidative phosphorylation, making it a foundational component of cellular ATP production. Beyond metabolism, NAD+ also functions as a required substrate for several enzyme systems, including sirtuins, poly(ADP-ribose) polymerases (PARPs), and CD38, linking it to pathways associated with cellular regulation and stress response.
Due to these broad biological roles, NAD+ has become an important research focus in studies related to aging biology, metabolic control, and cellular resilience under stress conditions. Its involvement in DNA repair-related enzyme activity also makes it valuable in research examining genomic stability and cellular recovery processes.
Research applications include investigation of:
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cellular metabolism and mitochondrial function
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aging and longevity-related mechanisms
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DNA repair and cellular stress pathways
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NAD+-dependent enzyme systems (sirtuins, PARPs, CD38)
For research use only.
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